Asprosin, a Fasting-Induced Glucogenic Protein Hormone.

TitleAsprosin, a Fasting-Induced Glucogenic Protein Hormone.
Publication TypeJournal Article
Year of Publication2016
AuthorsRomere, C, Duerrschmid, C, Bournat, J, Constable, P, Jain, M, Xia, F, Saha, PK, Del Solar, M, Zhu, B, York, B, Sarkar, P, Rendon, DA, M Gaber, W, LeMaire, SA, Coselli, JS, Milewicz, DM, V Sutton, R, Butte, NF, Moore, DD, Chopra, AR
Date Published2016 Apr 21
KeywordsAdipose Tissue, White, Amino Acid Sequence, Animals, Antibodies, Circadian Rhythm, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Fasting, Female, Fetal Growth Retardation, Glucose, Humans, Insulin, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Obese, Microfilament Proteins, Molecular Sequence Data, Peptide Fragments, Peptide Hormones, Progeria, Recombinant Proteins, Sequence Alignment

Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G protein-cAMP-PKA pathway, resulting in rapid glucose release into the circulation. Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of function via immunologic or genetic means has a profound glucose- and insulin-lowering effect secondary to reduced hepatic glucose release. Asprosin represents a glucogenic protein hormone, and therapeutically targeting it may be beneficial in type II diabetes and metabolic syndrome.

Alternate JournalCell
PubMed ID27087445
PubMed Central IDPMC4852710
Grant ListP60 DK020593 / DK / NIDDK NIH HHS / United States
U54 HG006542 / HG / NHGRI NIH HHS / United States
K08 DK102529 / DK / NIDDK NIH HHS / United States
P30 DK079638 / DK / NIDDK NIH HHS / United States
P30 DK020593 / DK / NIDDK NIH HHS / United States
P50 HL083794 / HL / NHLBI NIH HHS / United States
U24 DK059637 / DK / NIDDK NIH HHS / United States